Michael S Wolfe Selected Research

Aspartic Acid Proteases

1/2020	Unraveling the complexity of γ-secretase.
11/2019	Designed Helical Peptides as Functional Probes for γ-Secretase.
12/2013	Toward the structure of presenilin/γ-secretase and presenilin homologs.
6/2012	A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing.
5/2009	Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing.
6/2006	Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking.

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Michael S Wolfe Research Topics

Disease

86	Alzheimer Disease (Alzheimer's Disease) 03/2022 - 03/2002
5	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2013 - 08/2006
3	Dementia (Dementias) 07/2021 - 01/2014
3	Neoplasms (Cancer) 04/2009 - 10/2007
2	Cognitive Dysfunction 03/2022 - 12/2010
2	Neuroblastoma 01/2021 - 12/2013
2	Amyloid Plaque 12/2017 - 11/2004
1	Amyloidosis 03/2022
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2014
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2012
1	Nervous System Diseases (Neurological Disorders) 01/2012
1	Frontotemporal Dementia (Semantic Dementia) 01/2012
1	Memory Disorders (Memory Loss) 12/2010
1	Glioma (Gliomas) 06/2005
1	Pancreatic Neoplasms (Pancreatic Cancer) 06/2003
1	Carcinogenesis 06/2003
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2003

Drug/Important Bio-Agent (IBA)

56	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022 - 04/2002
39	Amyloid (Amyloid Fibrils)IBA 01/2022 - 04/2002
38	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
33	Peptides (Polypeptides)IBA 03/2022 - 04/2002
24	Amyloid beta-PeptidesIBA 01/2021 - 04/2002
17	PresenilinsIBA 01/2020 - 12/2002
16	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 03/2002
8	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 01/2021 - 08/2002
8	EnzymesIBA 01/2019 - 10/2003
7	Pharmaceutical PreparationsIBA 07/2021 - 06/2005
6	Flavin-Adenine Dinucleotide (FAD)IBA 07/2021 - 01/2019
6	Aspartic Acid ProteasesIBA 01/2020 - 06/2006
5	Notch ReceptorsIBA 04/2009 - 01/2003
4	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019 - 03/2002
4	Protein Isoforms (Isoforms)IBA 06/2016 - 06/2008
4	tau Proteins (tau Protein)IBA 06/2014 - 05/2009
3	RNA Precursors (Precursor, mRNA)IBA 06/2014 - 11/2009
2	Biological ProductsIBA 01/2019 - 06/2015
2	Messenger RNA (mRNA)IBA 01/2014 - 05/2009
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2012 - 08/2006
2	Staphylococcal Protein A (Protein A)IBA 05/2009 - 10/2003
2	Gamma Secretase Inhibitors and ModulatorsIBA 04/2009 - 06/2008
1	Biomarkers (Surrogate Marker)IBA 03/2022
1	PeptidomimeticsIBA 01/2021
1	Antisense OligonucleotidesIBA 01/2014
1	LuciferasesIBA 12/2013
1	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 06/2012
1	RNA IsoformsIBA 06/2012
1	Phosphodiesterase 5 InhibitorsIBA 12/2010
1	Pregnanolone (Allopregnanolone)IBA 12/2010
1	Protein Tyrosine PhosphatasesIBA 12/2010
1	GABA-A Receptors (GABA(A) Receptor)IBA 12/2010
1	Mitoxantrone (Novantrone)FDA LinkGeneric 11/2009
1	ElementsIBA 11/2009
1	O-(glucuronic acid 2- sulfate)- (1- - 4)- O- (2,5)- anhydromannitol 6-sulfateIBA 06/2008
1	Presenilin-1IBA 02/2007
1	NucleotidesIBA 12/2005
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 06/2005
1	phthalocyanineIBA 06/2005
1	Photosensitizing Agents (Photosensitizers)IBA 06/2005
1	NestinIBA 06/2003
1	Transforming Growth Factor alpha (TGF-alpha)IBA 06/2003

Therapy/Procedure

6	Therapeutics 07/2021 - 06/2005
1	Photochemotherapy (Photodynamic Therapy) 06/2005